Principal Investigators
Dr. Ryan Zarychanski, M.D. MSc
Ryan Zarychanski is a Critical Care physician, Hematologist, and Clinician Scientist at the University of Manitoba and CancerCare Manitoba, and is an active member of the CCCTG.
Dr. Zarychanski completed combined fellowships in Critical Care Medicine and Hematology, (University of Manitoba) followed by a Masters degree in Epidemiology and a research fellowship (University of Ottawa) under Drs. Dean Fergusson and Paul Hebert. Dr. Zarychanski’s research focuses on the hematologic aspects of critical illness. His major research program evaluates the efficacy and safety of unfractionated heparin in septic shock – a program that has evolved, with close collaboration from the CCCTG, into an international multicentre randomized controlled trial; the HALO International RCT. Other active programs of research include evaluating IVIG in septic shock, studying the role of Tranexamic acid to reduce transfusion in major non-cardiac surgery, and improving processes of care for patients requiring massive transfusion. He also leads research evaluating thrombocytopenia, transfusion, and anemia in critical illness. Dr. Zarychanski actively supervises graduate students and clinical investigators pursuing careers as clinician-scientists.
Anand Kumar, M.D.
Dr Anand Kumar is a Professor of Medicine (Critical Care Medicine and Infectious Diseases), Medical Microbiology and Pharmacology/Therapeutics at the University of Manitoba and an attending physician at the Health Sciences Centre and St. Boniface Hospital, Winnipeg, Manitoba, Canada. He earned his medical degree from the University of Toronto in Ontario, Canada and completed his residency in Internal Medicine at the Toronto Hospital—University of Toronto. Dr Kumar subsequently completed Fellowships in Critical Care Medicine and Cardiovascular Research at Rush-Presbyterian-St Luke’s Medical Center in Chicago and Infectious Diseases at the University of Wisconsin Hospital and Clinics in Madison, Wisconsin. Dr. Kumar is trained in Internal Medicine, Critical Care Medicine and Infectious Diseases with translational research interests in sepsis and life-threatening infections. He has published over 450 original research manuscripts, reviews/chapters and abstracts.
Dean Fergusson, MHA, PhD
Dr. Fergusson is a Senior Scientist & Director, Clinical Epidemiology Program, at the Ottawa Hospital Research Institute. He is also a Full Professor, Departments of Medicine, Surgery, & of the School of Epidemiology and Public Health, University of Ottawa. Dr. Fergusson holds the position of Endowed Chair, OHRI/uOttawa, Clinical Epidemiology Program.
He holds a PhD (Honours) in Epidemiology and Biostatistics from McGill University and a Masters of Health Administration from the University of Ottawa. Dr. Fergusson’s clinical research interests are mainly in the field of transfusion medicine with a focus on transfusion alternatives and the effectiveness of blood products. His research interests also extend to the methodology and ethics of clinical trials and systematic reviews. Dr. Fergusson is a principal investigator on a number of large, peer-reviewed clinical trials in transfusion medicine including “Blood Conservation Using Antifibrinolytics: Randomized Trial in High-Risk Cardiac Surgery (BART)”, Age of Red Blood Cells in Premature Infants (ARIPI), “Age of Blood Evaluation (ABLE)”. Dr. Fergusson has contributed over 380 articles, abstracts, and book chapters to the medical literature.
Multi-Centre Coordinator | Project Lead
Nicole Marten, RN
Nicole Marten completed her diploma of nursing in 1988 at St. Boniface Hospital Diploma School of Nursing followed by the completion of the Intensive Care Certificate in 1990. She worked in the Surgical Intensive Care Unit from 1990 – 1999. In 1999 she began her career in Clinical Research. She worked as a Respiratory Research Nurse for 7 years, which included some ICU trials and then moved to Interventional Cardiology Research. In November 2007 she was the successful candidate for the Critical Care Research Nurse position which included coordinating clinical trials at both St. Boniface and Grace Hospitals. In 2011 Nicole began working with Dr. Ryan Zarychanski on the HALO pilot study that evaluated the efficacy and safety of unfractionated heparin in septic shock – a program that has now evolved, with close collaboration from the CCCTG (Canadian Critical Care Trials Group), into a multi-centre international randomized controlled trial. Nicole now acts as the project lead and multi-centre coordinator for this international clinical trial. She also has a special interest in the psychological well-being of ICU survivors and was actively involved with a local, single center pilot study testing the feasibility of a diary intervention in the ICU.
Steering Committee
Data Safety Monitoring Board
Steve Webb, MD
CLINICAL PROFESSOR | UNIVERSITY OF WESTERN AUSTRALIA, PERTH
Richard Hall, MD, FRCPC, FCCP
DALHOUSIE UNIVERSITY | NOVA SCOTIA, CANADA
Lehana Thabane BSc, MSc, PhD
MCMASTER UNIVERSITY | ONTARIO, CANADA
Dr. Steven Opal, MD
PROFESSOR OF MEDICINE | BROWN UNIVERSITY, RHODE ISLAND, USA
Dr. Anders Perner, MD
PROFESSOR | COPENHAGEN UNIVERSITY, DENMARK
Trial Sites
HEALTH SCIENCES CENTRE | WINNIPEG, MB
Principal Investiagor: Dr. Ryan Zarychanski
Research Coordinator: Maggie Wilson
ST BONIFACE HOSPITAL | WINNIPEG, MB
Principal Investigator: Dr. Anand Kumar
Research Coordinator: Maggie Wilson
VANCOUVER ISLAND HEALTH AUTHORITY | VANCOUVER, BC
Principal Investigator: Dr. Gordon Wood
Research Coordinators: Fiona Auld | Gayle Carney
CHU DE QUÉBEC - UNIVERSITÉ LAVAL, HÔPITAL DE L’ENFANT JÉSUS | QUÉBEC CITY, PQ
Principal Investigator : Dr. Alexis Turgeon
Research Coordinator : David Bellemare
ST MICHAEL’S HOSPITAL | TORONTO, ON
Principal Investigator : Dr. Jan Friedrich / Dr John Marshall
Research Coordinator: Marlene Santos
OTTAWA HOSPITAL | OTTAWA, ON
Principal Investigator: Lauralyn McIntyre
Research Coordinators: Irene Watpool | Rebecca Porteous | Brigette Gomes
NIAGARA HEALTH | ST. CATHARINES, ON
Principal Investigator: Dr. Jennifer Tsang
Research Coordinator: Mercedes Camargo
CENTRE HOSPITALIER DE L’UNIVERSITÉ DE MONTRÉAL (CHUM) | MONTRÉAL, PQ
Principal Investigator: Dr. François Martin Carrier
Research Coordinator: Valerie Tran
INSTITUT UNIVERSITAIRE DE CARDIOLOGIE ET DE PNEUMOLOGIE DE QUÉBEC - UNIVERSITÉ LAVAL | QUÉBEC, PQ
Principal Investigator: Dr. François Lellouche
Research Coordinator: Patricia Lizotte
FOOTHILLS MEDICAL CENTRE
Principal Investigator: Dr. Brent Winston
Research Coordinator: Stacy Ruddell
HCOR RESEARCH INSTITUTE | SAO PAULO
CEO: Dr Alexandre Biasi Cavalcanti
Clinical Researcher Coordinator: Dr Fernando Godinho Zampieri
Site Management Coordinator: Lígia Nasi Laranjeira
Regulatory Affairs Management, Coordinator: Nanci Valeis
HOSPITAL SIRIO LIBANES | SAO PAULO
Principal Investigator: Dr. Ludhmila Hajjar
Research Coordinator: Ligia Camara
HOSPITAL PAULISTANO
Principal Investigator: Dr. Airton Leonardo de Oliveira Manoel
Team Member: Perla Melo Andrade
HC FMUSP
Principal Investigator: Dr. Leandro Utino Taniguchi
INSTITUTO DE ASSISTÊNCIA MÉDICA AO SERVIDOR PÚBLICO ESTADUAL DE SÃO PAULO
Principal Investigator: Dr. João Manoel Silva Junior
Team Member: Flavio Araújo dos Santos
INSTITUTO DE CARDIOLOGIA DO DISTRITO FEDERAL
Principal Investigator: Dr. Rodrigo Santos Biondi
Team Member: Klicia Barbosa Bezerra Matioli
HOSPITAL NOVO ATIBAIA
Principal Investigator: Dr. Manoela Moreira de Sousa
HOSPITAL BAÍA SUL S.A.
Principal Investigator: Dr. Israel Silva Maia
Team Member: Andreia Ribeiro da Rocha
HOSPITAL NEREU RAMOS
Principal Investigator: Dr. Israel Silva Maia
Team Member: Cassio Zandonai
HOSPITAL DAS CLÍNICAS DA FACULDADE DE MEDICINA DE RIBEIRÃO
Principal Investigator: Dr. Wilson José Lovato
Team Member: Rodrigo Barbosa Cerantola
HOSPITAL DA LUZ VILA MARIANA
Principal Investigator: Dr. Bruno Adler Maccagnan Pinheiro Besen
Team Member: Eliana Vieira do Nascimento Martins
FUNDACAO DO ABC
Principal Investigator: Dr. Caio Cesar Ferreira Fernandes
Team Member: Andressa Tomochigue dos Anjos
SOCIEDADE LITERARIA E CARITATIVA SANTO AGOSTINHO
Principal Investigator: Dr. Felipe Dal Pizzol
Team Member: Danusa de Castro Damasio
HOME - HOSPITAL ORTOPEDICO E MEDICINA ESPECIALIZADA LTDA.
Principal Investigator: Dr. Antonio Aurélio de Paiva Fagundes Jr.
Team Member: Thais Coutinho
UNIVERSIDADE FEDERAL DE SÃO PAULO - UNIFESP/EPM
Principal Investigator: Dr. Hélio Penna Guimarães
Team Member: Marcos Cesar Ramos Mello
HOSPITAL ANA NERY
Principal Investigator: Dr. Rodrigo Morel Vieira de Melo
Team Member: Daniela Dorta
IRMANDADE DA SANTA CASA DE MISERICÓRDIA DE PORTO ALEGRE
Principal Investigator: Dr. Thiago Costa Lisboa
Team Member: Martha Hädrich
HOSPITAL DO CANCER DE BARRETOS
Principal Investigator: Dr. Cristina Prata Amendola
Team Member: Ligia Zampieri
SANTA CASA DA MISERICORDIA DE SAO JOAO DEL REI
Principal Investigator: Dr. Jorge Luiz da Rocha Paranhos
Team Member: Iany Silva
HOSPITAL GERAL DE CAXIAS DO SUL
Principal Investigator: Dr. Emerson Boschi da Silva
Team Member: Scheila Hoffman
HOSPITAL E MATERNIDADE BRASIL
Principal Investigator: Dr. Sylas Bezerra Cappi
Team Member: Simone Cinini
HOSPITAL DE JALES
Principal Investigator: Dr. Pablo Oscar Tomba
Team Member: Joice Ramos de Almeida
HOSPITAL MUNICIPAL DA VILA SANTA CATARINA
Principal Investigator: Dr. Luciana Gioli Pereira
Team Member: Ana Lucia Neves
HOSPITAL AC CAMARGO
Principal Investigator: Dr. Antonio Paulo Nassar Junior
HOSPITAL BP MIRANTE
Principal Investigator: Dr. Gustavo Niankowski Saliba
HOSPITAL E MATERNIDADE SÃO VICENTE
Principal Investigator: Dr. Thales Aníbal Leite Barros Agostinho
Team Member: Kiara Monteiro de Andrade
HOSPITAL DAS CLÍNICAS, FACULDADE DE MEDICINA DA UNIVERSIDADE DE SÃO PAULO
Principal Investigator: Dr. Ludhmila Abrahao Hajjar
Team Member: Ligia Camara
ATTIKON UNIVERSITY HOSPITAL | ATHENS
Principal Investigator: Dr. Evangelos J. Giamarellos
Research staff: Nicky Solomonidi
INDORIV CLINICAL | WEST BENGAL
Founder: Anant Agarwal
AMRI HOSPITAL KOLKATA | WEST BENGAL
Principal Investigator: Dr. Subash Todi
THE INDUS HOSPITAL | KARACHI
Principal Investigator: Dr. Samreen Sarfaraz
DOW UNIVERSITY OF HEALTH SCIENCES (SMBBIT AND CIVIL HOSPITAL) | KARACHI
Principal Investigator: Dr. Sadqa Aftab
PHILIPPINE GENERAL HOSPITAL | MANILA
Principal Investigator: Dr Marissa Alejandria
THE MEDICAL CITY | PASIG CITY
Principal Investigator: Jose Emmanuel Palo
THE ASIAN HOSPITAL | MANILA
Principal Investigator: Dr. Joseph Buensalido
TYGERBERG HOSPITAL | CAPE TOWN
Principal Investigator: Dr. Sean Chetty
FROEDTERT HOSPITAL | MILWAUKEE, WI
Principal Investigator: Dr. Rahul Nancha
Research Coordinator: Stephanie Zellner
Data Management Services
OHRI-CEP, Ottawa Methods Centre (OMC)
Dong Vo, Manager, DMS
Tel (613) 737-8899 Ext.73804
Email: dvo@ohri.ca
“The Ottawa Methods Centre-DMS is a team of experienced web application developers & database designers.”